Bisphosphonates in multiple myeloma: an updated network meta-analysis.

  title={Bisphosphonates in multiple myeloma: an updated network meta-analysis.},
  author={Rahul S. Mhaskar and Ambuj Kumar and Branko Miladinovic and Benjamin Djulbegovic},
  journal={The Cochrane database of systematic reviews},
BACKGROUND Bisphosphonates are specific inhibitors of osteoclastic activity and are used in the treatment of patients with multiple myeloma (MM). While bisphosphonates are shown to be effective in reducing vertebral fractures and pain, their role in improving overall survival (OS) remains unclear. This is an update of a Cochrane review first published in 2002 and previously updated in 2010 and 2012. OBJECTIVES To assess the evidence related to benefits and harms associated with use of various… CONTINUE READING
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