Bisphosphonates in breast cancer: clinical activity and implications of preclinical data.

  • Rebecca L. Aft
  • Published 2011 in Clinical advances in hematology & oncology : H&O


Breast cancer is the most frequently diagnosed and second deadliest cancer among women. Bisphosphonates are stable pyrophosphate analogues used to treat skeletal-related events resulting from bone metastases. In the adjuvant setting, they have been shown to prevent aromatase inhibitor-associated and chemotherapy-induced bone loss. There is a growing body of evidence that bisphosphonates have direct and indirect anticancer activity in the preclinical and clinical settings. These include the inhibition of tumor growth; induction of apoptosis; synergism with chemotherapy; inhibition of tumor migration, invasion, and metastasis; reduction in disseminated tumor cells; inhibition of angiogenesis; stimulation of immune surveillance; and suppression of bone-derived growth factors. In addition to reducing the risk of breast cancer, bisphosphonate therapy has been shown to improve outcomes of early and metastatic breast cancer treatment. This review provides a brief overview of the current role of bisphosphonates in clinical practice and discusses their potential as anticancer agents.

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Cite this paper

@article{Aft2011BisphosphonatesIB, title={Bisphosphonates in breast cancer: clinical activity and implications of preclinical data.}, author={Rebecca L. Aft}, journal={Clinical advances in hematology & oncology : H&O}, year={2011}, volume={9 3}, pages={194-205} }