Bisphosphonates in bone diseases

  title={Bisphosphonates in bone diseases},
  author={Rolf W. Sparidans and Irene M. Twiss and Stephanie Talbot},
  journal={Pharmacy World and Science},
Bisphosphonates are a class of drugs which are strongly attracted to the bone where they influence the calcium metabolism, mainly by inhibition of the osteoclast-mediated bone resorption. This property makes these compounds suited for the treatment of several diseases of the bone. In Paget's disease, several bisphosphonates can reduce bone pain and decrease the bone turnover 60‐70%. Cyclical oral etidronate and daily oral alendronate both proved to reduce the vertebral fracture rate for… CONTINUE READING
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