Bisphosphonates in Complex Regional Pain syndrome type I: how do they work?

@article{Varenna2014BisphosphonatesIC,
  title={Bisphosphonates in Complex Regional Pain syndrome type I: how do they work?},
  author={Massimo Varenna and Silvano Adami and Luigi Sinigaglia},
  journal={Clinical and experimental rheumatology},
  year={2014},
  volume={32 4},
  pages={451-4}
}
Complex Regional Pain syndrome type I (CRPS-I) is a disease characterised by extreme pain for which no gold-standard treatment exists to date. In recent years a possible role for bisphosphonates in the treatment of CRPS-I has been proposed. These drugs were first used for their effect in decreasing pain in bone diseases in which bisphosphonates act through their antiosteoclastic properties (metastatic disease, Paget disease, myeloma). In CRPS-I, enhanced osteoclastic activity has never clearly… CONTINUE READING
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