Bisphosphonates for the treatment of Charcot neuroarthropathy.

  title={Bisphosphonates for the treatment of Charcot neuroarthropathy.},
  author={John J. B. Anderson and Kirk E Woelffer and John J Holtzman and Allen Mark Jacobs},
  journal={The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons},
  volume={43 5},
Excess osteoclastic activity is believed to be responsible for the destruction in Charcot neuropathic joint disease. By intervening early in the destructive process, it may be possible to halt the progression toward the devastating bone and joint deformity responsible for morbidity in Charcot feet. This retrospective study evaluated the effects of the bisphosphonate pamidronate on associated signs of Charcot. The 13 study patients (14 infusions) administered pamidronate were compared with 10… CONTINUE READING
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