Bisphosphonates directly regulate cell proliferation, differentiation, and gene expression in human osteoblasts.

@article{Reinholz2000BisphosphonatesDR,
  title={Bisphosphonates directly regulate cell proliferation, differentiation, and gene expression in human osteoblasts.},
  author={G G Reinholz and B Getz and L Pederson and Emily S. Sanders and M Subramaniam and James N. Ingle and Thomas C. Spelsberg},
  journal={Cancer research},
  year={2000},
  volume={60 21},
  pages={6001-7}
}
Bisphosphonates are widely used clinically to treat bone diseases in which bone resorption is in excess. However, the mechanism of bisphosphonate action on bone is not fully understood. Studies of direct action of bisphosphonates on bone have been limited mainly to their effects on bone-resorbing osteoclast cells, with implications that some activity may be mediated indirectly through paracrine factors produced by the bone-forming osteoblast cells. Little is known about the direct effects of… CONTINUE READING
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