Bisphosphonates as anticancer drugs.

  title={Bisphosphonates as anticancer drugs.},
  journal={Expert opinion on investigational drugs},
  volume={8 12},
  • Mundy
  • Published 1999 in Expert opinion on investigational drugs
The single most important advance in the last few years in the treatment of patients with osteolytic bone disease due to malignancy has been the widespread use of pamidronate; this drug has been used in patients with breast cancer metastatic to bone, and in patients with myeloma, with or without hypercalcaemia. However, data are now emerging which suggest that bisphosphonates have additional, and completely unanticipated, effects beyond those on bone resorption. Studies of the behaviour of… CONTINUE READING


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