Bisphosphonates as a supplement to exercise to protect bone during long-duration spaceflight

@article{Leblanc2012BisphosphonatesAA,
  title={Bisphosphonates as a supplement to exercise to protect bone during long-duration spaceflight},
  author={Adrian L Leblanc and Toshio Matsumoto and Josh J. Jones and Jay Shapiro and Thomas Lang and Linda C. Shackelford and Scott M. Smith and Harlan Evans and Elena Spector and Robert Ploutz-Snyder and Jean D. Sibonga and Joyce H. Keyak and Toshitaka Nakamura and Kenjiro Kohri and Hiroshi Ohshima},
  journal={Osteoporosis International},
  year={2012},
  volume={24},
  pages={2105-2114}
}
We report the results of alendronate ingestion plus exercise in preventing the declines in bone mass and strength and elevated levels of urinary calcium and bone resorption in astronauts during 5.5 months of spaceflight. This investigation was an international collaboration between NASA and the JAXA space agencies to investigate the potential value of antiresorptive agents to mitigate the well-established bone changes associated with long-duration spaceflight. We report the results from seven… CONTINUE READING
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