Bisphosphonates and osteomyelitis of the jaw: a pathogenic puzzle

  title={Bisphosphonates and osteomyelitis of the jaw: a pathogenic puzzle},
  author={Francesco Bertoldo and Daniele Santini and Vincenzo Lo Cascio},
  journal={Nature Clinical Practice Oncology},
The maxillary and mandibular bones undergo high-turnover remodeling to maintain mechanical competence. Common dental or periodontal diseases can increase local bone turnover. Bisphosphonates (BPs) accumulate almost exclusively in skeletal sites that have active bone remodeling. The maxillary and mandibular bones are preferential sites for accumulation of BPs, which become buried under new layers of bone and remain biologically inactive for a long time. Surgical odontostomatological procedures… CONTINUE READING


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