Bisphosphonates and osteomyelitis of the jaw: a pathogenic puzzle

@article{Bertoldo2007BisphosphonatesAO,
  title={Bisphosphonates and osteomyelitis of the jaw: a pathogenic puzzle},
  author={Francesco Bertoldo and Daniele Santini and Vincenzo Lo Cascio},
  journal={Nature Clinical Practice Oncology},
  year={2007},
  volume={4},
  pages={711-721}
}
The maxillary and mandibular bones undergo high-turnover remodeling to maintain mechanical competence. Common dental or periodontal diseases can increase local bone turnover. Bisphosphonates (BPs) accumulate almost exclusively in skeletal sites that have active bone remodeling. The maxillary and mandibular bones are preferential sites for accumulation of BPs, which become buried under new layers of bone and remain biologically inactive for a long time. Surgical odontostomatological procedures… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 39 extracted citations

The use of bisphosphonates in women: when to use and when to stop.

Expert opinion on pharmacotherapy • 2015
View 9 Excerpts
Highly Influenced

Bisphosphonate Related Osteonecrosis of the Jaw: An Update.

Journal of maxillofacial and oral surgery • 2014
View 5 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 63 references

Bisphosphonates and osteonecrosis of the jaw: cause and effect or a post hoc fallacy?

Annals of oncology : official journal of the European Society for Medical Oncology • 2006

Effects of continuing or stopping alendronate after 5 years of treatment: the Fracture Intervention Trial Long-Term EXtension (FLEX): a randomized trial

D Black
J Am Med Ass • 2006

Insulin-like growth factor system components in the periodontium during tooth root resorption and early repair process in the rat

W Götz
Eur J Oral Sci • 2006

Molecular mechanisms of action of bisphosphonates: current status

AJ Roelofs
Clin Cancer Res • 2006

Osteonecrosis of the jaw in multiple myeloma patients : clinical features and risk factors

T Mavrokokki
J Clin Oncol • 2006

Osteonecrosis of the jaws in patients treated with bisphosphonates— histomorphologic analysis in comparison with infected osteoradionecrosis

T Hansen
J Oral Pathol Med • 2006

Practical guidelines for the prevention, diagnosis, and treatment of osteonecrosis of the jaw in patients with cancer

S Ruggiero
J Oncol Pract • 2006

Similar Papers

Loading similar papers…