Bisphosphonates activate nucleotide receptors signaling and induce the expression of Hsp90 in osteoblast-like cell lines.

@article{Romanello2006BisphosphonatesAN,
  title={Bisphosphonates activate nucleotide receptors signaling and induce the expression of Hsp90 in osteoblast-like cell lines.},
  author={Milena Romanello and Nicoletta Bivi and Alex Pines and Marta Deganuto and Franco Quadrifoglio and L. C. Moro and Gianluca Tell},
  journal={Bone},
  year={2006},
  volume={39 4},
  pages={739-53}
}
Bisphosphonates are the most important drugs used in the treatment of osteoporosis as they inhibit osteoclast resorption and stimulate proliferation of osteoblasts. However, the molecular mechanisms responsible for these effects are still poorly elucidated. It is known that nucleotide receptors-mediated signaling plays a central role in modulating osteoblasts growth in response to mechanical stress. By using osteoblast-like cell lines (i.e., HOBIT, MG-63, ROS P2Y), which express P2Y receptors… CONTINUE READING
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