Bisphosphonates: how do they work?

  title={Bisphosphonates: how do they work?},
  author={Socrates E Papapoulos},
  journal={Best practice & research. Clinical endocrinology & metabolism},
  volume={22 5},
Bisphosphonates (BPs) are taken up preferentially by the skeleton and decrease osteoclast-mediated bone resorption. The capacity of the skeleton to retain BPs is large, and there is no indication for saturation of binding sites with the doses used in osteoporosis. The anti-resorptive action of BPs includes their selective binding to calcium crystals and their subsequent release and uptake by the osteoclasts. There are differences in the affinities of PBs for bone as well as in their anti… CONTINUE READING