Bisphosphonates: from bench to bedside.

@article{Russell2006BisphosphonatesFB,
  title={Bisphosphonates: from bench to bedside.},
  author={R Graham Russell},
  journal={Annals of the New York Academy of Sciences},
  year={2006},
  volume={1068},
  pages={
          367-401
        }
}
The discovery and development of the bisphosphonates (BPs) as a major class of drugs for the treatment of bone diseases has been a fascinating journey that is still not over. In clinical medicine, several BPs are established as the treatments of choice for various diseases of excessive bone resorption, including Paget's disease of bone, myeloma and bone metastases, and osteoporosis. Bisphosphonates are chemically stable analogues of inorganic pyrophosphate, and are resistant to breakdown by… CONTINUE READING

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