Bisphosphonate therapy in multiple myeloma: past, present, future.

  • Esa Jantunen
  • Published 2002 in European journal of haematology


Bone disease characterised by osteolytic lesions, pathological fractures and hypercalcaemia is an important clinical feature in multiple myeloma. Pain, decreased performance status, and the need for palliative radiotherapy and surgical interventions are common sequelae. Bisphosphonates act primarily on osteoclasts to inhibit excessive bone resorption, and… (More)


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