Bisphosphonate risedronate reduces metastatic human breast cancer burden in bone in nude mice.

  title={Bisphosphonate risedronate reduces metastatic human breast cancer burden in bone in nude mice.},
  author={Akira Sasaki and Brendan F. Boyce and Beryl Story and Kenneth R. Wright and Matthew Chapman and Rogely Boyce and Gregory R. Mundy and T. Yoneda},
  journal={Cancer research},
  volume={55 16},
Human breast cancer frequently metastasizes to the skeleton to cause osteolysis and subsequent pain, pathological fracture, and hypercalcemia. Because bone continuously releases growth factors stored in bone matrix by bone resorption during physiological remodeling and, thus, possibly provides a favorable microenvironment for metastatic breast cancer cells to proliferate, inhibitors of bone resorption used either prophylactically or in patients with established disease, therefore, would seem… CONTINUE READING


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