Bisphosphonate risedronate reduces metastatic human breast cancer burden in bone in nude mice.

@article{Sasaki1995BisphosphonateRR,
  title={Bisphosphonate risedronate reduces metastatic human breast cancer burden in bone in nude mice.},
  author={Akira Sasaki and Brendan F. Boyce and Beryl Story and Kenneth R. Wright and Matthew Chapman and Rogely Boyce and Gregory R. Mundy and T. Yoneda},
  journal={Cancer research},
  year={1995},
  volume={55 16},
  pages={3551-7}
}
Human breast cancer frequently metastasizes to the skeleton to cause osteolysis and subsequent pain, pathological fracture, and hypercalcemia. Because bone continuously releases growth factors stored in bone matrix by bone resorption during physiological remodeling and, thus, possibly provides a favorable microenvironment for metastatic breast cancer cells to proliferate, inhibitors of bone resorption used either prophylactically or in patients with established disease, therefore, would seem… CONTINUE READING

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View 2 Excerpts
Highly Influenced

Bisphosphonates: mechanisms of action.

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View 3 Excerpts
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References

Publications referenced by this paper.
Showing 1-10 of 27 references

Pharmacology and use in the treatment of tumorinduced hypercalcemia and metastatic bone disease

Fleisch, H. Bisphosphonates
Drugs, • 1991
View 3 Excerpts
Highly Influenced

Bisphosphonates: pharmacology.

Seminars in arthritis and rheumatism • 1994

Effect of the bisphosphonate risedronate on bone métas tases in a ral mammary adenocarcinoma model system

G Hall.D., G. Stoica
J. Bone Miner. Res., • 1994
View 2 Excerpts

Osteolytic bone disease in breast cancer

Yoneda, A.T.. Sasaki, G R.Mundy.
Breast Cancer Res. Treat., • 1994
View 1 Excerpt

Incidence and distribution of experimental métastasesin mutant mice with defective organ microenvironment (Genotype SI/Sld and W/W^)

Arguello. F.. Fulanetto, R.B.R.W.. Baggs, +3 authors C. N. Frantz
Cancer Res., • 1992

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