Bisphosphonate long-term treatment related bilateral subtrochanteric femoral fracture. Can teriparatide be useful?

Abstract

Long-term treatment with bisphosphonates has been related to atypical femoral fractures. We report the clinical case of a woman who suffered a proximal diaphyseal oblique fracture of the left femur after uninterrupted 13-year treatment with alendronate. Shortly after surgery, a painful lytic image in the external cortex of her right femur diaphysis was detected. Some papers have suggested surgical treatment to repair femur fractures after long-term treatment with bisphosphonates. Otherwise, two studies have shown healing acceleration of bone fractures with teriparatide. A lytic lesion was treated with teriparatide obtaining progressive disappearance of symptoms as well as bone healing. This outcome may suggest a way of prevention of complete fractures in symptomatic patients with long-term treatment with bisphosphonates.

DOI: 10.1007/s40520-013-0137-3
0100200300201520162017
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@article{TarazonaSantabalbina2013BisphosphonateLT, title={Bisphosphonate long-term treatment related bilateral subtrochanteric femoral fracture. Can teriparatide be useful?}, author={Francisco Jos{\'e} Tarazona-Santabalbina and Luis Aguilella-Fern{\'a}ndez}, journal={Aging clinical and experimental research}, year={2013}, volume={25 5}, pages={605-9} }