Bisphosphonate‐Associated Osteonecrosis of the Jaw: Report of a Task Force of the American Society for Bone and Mineral Research

@article{Khosla2007BisphosphonateAssociatedOO,
  title={Bisphosphonate‐Associated Osteonecrosis of the Jaw: Report of a Task Force of the American Society for Bone and Mineral Research},
  author={Sundeep Khosla and David B. Burr and Jane A. Cauley and David W Dempster and Peter R. Ebeling and Dieter Felsenberg and Robert F. Gagel and Vincente Gilsanz and Theresa A. Guise and Sreenivas Koka and Laurie K McCauley and Joan A McGowan and Marc D. McKee and Suresh Mohla and David G. Pendrys and Lawrence G. Raisz and Salvatore L. Ruggiero and David M. Shafer and Lillian Shum and Stuart L. Silverman and Catherine H Van Poznak and Nelson B. Watts and Sook-Bin Woo and Elizabeth Shane},
  journal={Journal of Bone and Mineral Research},
  year={2007},
  volume={22}
}
ONJ has been increasingly suspected to be a potential complication of bisphosphonate therapy in recent years. Thus, the ASBMR leadership appointed a multidisciplinary task force to address key questions related to case definition, epidemiology, risk factors, diagnostic imaging, clinical management, and future areas for research related to the disorder. This report summarizes the findings and recommendations of the task force. 
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Bisphosphonates and osteonecrosis of the jaw: proceedings of an international conference

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Recent recommendations on bisphosphonate-associated osteonecrosis of the jaw.

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PURPOSE This is a case study of a patient with multiple myeloma presenting with bisphosphonate-associated osteonecrosis of the jaw after an extraction of tooth #18 while receiving intravenous…

Osteonecrosis of the Jaw: Meeting Report from Skeletal Complications of Malignancy V: October 25-27, 2007 in Philadelphia, Pennsylvania, USA

Since the earliest case suggesting an association of osteonecrosis of the jaw (ONJ) with bisphosphonate (BP) use in 2003, many other ONJ cases have been documented, highlighting the need for…

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Bisphosphonate-associated osteonecrosis of the jaw in breast cancer patients: recommendations for prevention and treatment.

OSTEONECROSIS OF THE JAW ASSOCIATED TO BISPHOSPHONATES TREATMENT IN OSTEOPOROSIS PATIENTS: A REVIEW

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Potential pathophysiological mechanisms in osteonecrosis of the jaw

Proposed mechanisms underlying ONJ development are explored and potential areas for future investigation are identified.
...

References

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Osteonecrosis of the Jaw: More Research Needed

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This editorial summarized the current evidence for an association between ONJ and bisphosphonates in doses used for osteoporosis and Paget’s disease and raised great concern among patients and health care professionals.

Bisphosphonates and osteonecrosis of the jaw.

This volumes seeks to improve awareness of the condition and the need for increased screening and improved diagnosis of ONJ and explores possible treatment options for ONJ to help guide future areas for research.

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Presentation of three patients showing therapy-resistant osteonecrosis of the mandible under bisphosphonate medication provides more information on this clinically important side effect of oral bisph phosphate medication, also in osteoporosis therapy.

Analysis of Frequency and Risk Factors for Developing Bisphosphonate Associated Osteonecrosis of the Jaw.

In MM pts the frequency of steroid treatment, parodonthopaties and anemia was particularly high, respectively 100%, 56%, and 56%, supporting the idea that these are additional risk factors for developing ONJ.

Nature and frequency of bisphosphonate-associated osteonecrosis of the jaws in Australia.

Managing the care of patients with bisphosphonate-associated osteonecrosis: an American Academy of Oral Medicine position paper.

Prevention of BON is the best approach to management of this complication and existing protocols to manage the care of patients who will receive radiation therapy or chemotherapy may be used until specific guidelines for BON are developed.

Osteonecrosis of the jaw and bisphosphonates

100 years ago the manufacture of matches using yellow phosphorus was subject to an International Convention in Berne (1906), which resulted in substitution of yellow phosphorus for phosphorus…
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