Bisphenol A suppresses Th1-type immune response in human peripheral blood mononuclear cells in vitro.

@article{Gostner2015BisphenolAS,
  title={Bisphenol A suppresses Th1-type immune response in human peripheral blood mononuclear cells in vitro.},
  author={Johanna M. Gostner and Emanuel Raggl and Kathrin Becker and Florian {\"U}berall and Harald Schennach and James E Pease and Dietmar Fuchs},
  journal={Immunology letters},
  year={2015},
  volume={168 2},
  pages={285-92}
}
Bisphenol A (BPA) is a widely used plasticizer, which came into focus because of its genotoxic and sensitizing potential. Besides its toxic properties, BPA is also well-known for its antioxidant chemical properties. This in vitro study investigated the interference of BPA with interferon-γ (IFN-γ)-induced tryptophan breakdown and neopterin production in human peripheral blood mononuclear cells (PBMC). The pro-inflammatory cytokine IFN-γ induces the conversion of the essential amino acid… CONTINUE READING
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