Bisphenol A inhibits compound action potentials in the frog sciatic nerve in a manner independent of estrogen receptors

@article{Mizuta2017BisphenolAI,
  title={Bisphenol A inhibits compound action potentials in the frog sciatic nerve in a manner independent of estrogen receptors},
  author={Kotaro Mizuta and T. Fujita and H. Yamagata and E. Kumamoto},
  journal={Biochemistry and Biophysics Reports},
  year={2017},
  volume={10},
  pages={145 - 151}
}
  • Kotaro Mizuta, T. Fujita, +1 author E. Kumamoto
  • Published 2017
  • Medicine, Chemistry
  • Biochemistry and Biophysics Reports
  • Although the endocrine disruptor bisphenol A (BPA) is reported to inhibit nerve conduction, the underlying mechanisms are unclear. Therefore, in the present study, we examined the effect of BPA on compound action potentials (CAPs) recorded from the frog sciatic nerve using the air-gap method. Treatment of the sciatic nerve with BPA (0.5 mM) for 20 min reduced the peak amplitude of the CAP by approximately 60% in a partially reversible manner. The reduction in the CAP peak amplitude was… CONTINUE READING
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