Bisphenol A induces apoptosis and G2-to-M arrest of ovarian granulosa cells.

  title={Bisphenol A induces apoptosis and G2-to-M arrest of ovarian granulosa cells.},
  author={Jiping Xu and Yutaka Osuga and Tetsu Yano and Yutaka Morita and Xiaohui Tang and Toshihiro Fujiwara and Yasushi Takai and Hirotaka Matsumi and Kaori Koga and Yuji Taketani and Osamu Tsutsumi},
  journal={Biochemical and biophysical research communications},
  volume={292 2},
We investigated the impact of bisphenol A (BPA) on murine ovarian granulosa cells. Ovarian granulosa cells were cultured with 100 fM to 100 microM BPA for 24 h to 72 h. BPA decreased granulosa cell viability in a dose- and time-dependent manner. The lowest concentration that induced a significant decrease was 100 pM (89.2 +/- 4.0% of the control). TUNEL analysis demonstrated that treatment with BPA increased apoptosis of granulosa cells in a dose- and time-dependent manner. In addition, flow… CONTINUE READING

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