Bisphenol A exposure and children’s behavior: A systematic review

@article{Ejaredar2017BisphenolAE,
  title={Bisphenol A exposure and children’s behavior: A systematic review},
  author={Maede Ejaredar and Yoonshin Lee and Derek J. Roberts and Reginald S. Sauve and Deborah Dewey},
  journal={Journal of Exposure Science and Environmental Epidemiology},
  year={2017},
  volume={27},
  pages={175-183}
}
Bisphenol A (BPA) is an endocrine disrupting chemical used to synthesize polycarbonate plastics and epoxy resins. Previous research suggests that exposure to it can alter children’s behavior. The objective of this study is to conduct a systematic review of the existing literature, examining associations between prenatal and childhood BPA exposure and behavior in children up to 12 years of age. We searched electronic bibliographic databases (MEDLINE, PubMed, EMBASE, PsycINFO, CINAHL, and ERIC… 
Prenatal maternal and childhood bisphenol a exposure and brain structure and behavior of young children
TLDR
It is suggested that prenatal maternal exposure to BPA may lead to alterations in white matter microstructure in preschool aged children, and that such alterations mediate the relationship between early life exposure to bisphenol A and internalizing problems.
The Impact of Bisphenol A on Thyroid Function in Neonates and Children: A Systematic Review of the Literature
TLDR
The presented studies offer data that suggest a negative correlation of BPA concentrations with TSH in children, a gender-specific manner of action, and a potential effect on proper neurodevelopment, however, the results are inconclusive with respect to specific thyroid hormone concentrations and the effect on thyroid autoimmunity.
Prenatal exposure to bisphenol A and autistic- and ADHD-related symptoms in children aged 2 and5 years from the Odense Child Cohort
TLDR
Pregnant BPA exposure even in low concentrations may increase the risk of ASD symptoms which may predict later social abilities, and it is therefore important to follow-up these children at older ages, measure their own BPA Exposure, and determine if the observed associations persist.
Bisphenol A shapes children’s brain and behavior: towards an integrated neurotoxicity assessment including human data
TLDR
A future reevaluation of BPA focused on neurotoxicity is proposed, based on a systematic and comprehensive integration of available mechanistic, animal, and human data, which concludes that BPA is a probable developmental neurotoxicant at low doses.
A Systematic Review of Bisphenol A from Dietary and Non-Dietary Sources during Pregnancy and Its Possible Connection with Fetal Growth Restriction: Investigating Its Potential Effects and the Window of Fetal Vulnerability
TLDR
There is mounting evidence that combined exposure to BPA from dietary and non-dietary sources during pregnancy may contribute to abnormal fetal growth; a tendency towards fetal growth restriction was shown, especially when exposure occurs during the first half.
Associations between Exposure to Bisphenol A and Behavioral and Cognitive Function in Children with Attention-deficit/Hyperactivity Disorder: A Case-control Study
  • S. Yoo, H. Joo, K. Kim
  • Psychology
    Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology
  • 2020
TLDR
Exposure to BPA was associated with unfavorable behavioral and cognitive outcomes, and differences of behavior and cognition among three BPA groups were observed in only boys and normal controls.
Assessment of Bisphenol A Levels in Preschool Children: Results of a Human Biomonitoring Study in Ankara, Turkey
TLDR
The estimated daily BPA intake in this study is substantially lower than the European Food Safety Authority derived tolerable daily intake of 4 μg/kg BW/day.
Human-Biomonitoring derived exposure and Daily Intakes of Bisphenol A and their associations with neurodevelopmental outcomes among children of the Polish Mother and Child Cohort Study
TLDR
The exposure level was found to be related to child emotional condition, which can have long-term consequences including social functioning and scholastic achievements and further monitoring of this population in terms of overall chemical exposure is required.
Prenatal exposure to bisphenol A and phthalates and behavioral problems in children at preschool age: the Hokkaido Study on Environment and Children’s Health
TLDR
The authors' analyses found no significant association between BPA or summation of phthalate metabolite levels and any of the behavioral problems at 5 years of age but suggested possible association between MECPP levels and increased risk of conduct problems.
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TLDR
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