Bisphenol A disrupts steroidogenesis in human H295R cells.

@article{Zhang2011BisphenolAD,
  title={Bisphenol A disrupts steroidogenesis in human H295R cells.},
  author={Xiaowei Zhang and Hong Gang Chang and Steve B Wiseman and Yuhe He and Eric B Higley and Paul G. Jones and Chris Kong-Chu Wong and Abdulaziz A. Al-Khedhairy and John Paul Giesy and Markus Hecker},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2011},
  volume={121 2},
  pages={
          320-7
        }
}
There is increasing concern over the risk of environmentally relevant doses of bisphenol A (BPA) on human endocrine systems. Effects of BPA on steroidogenesis and the related molecular mechanisms were investigated in H295R human adenocarcinoma cells. This immortal cell line is unique in expressing all the enzymes of the steroidogenic pathways. The effects of BPA on steroidogenesis, 17β-estradiol (E2) metabolism, and aromatase activity were examined in H295R cells exposed to BPA from 3.0 × 10(-1… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 27 REFERENCES

Assessment of chemical effects on aromatase activity using the H295R cell line

Eric B. Higley, John L. Newsted, Xiaowei Zhang, John P. Giesy, Markus Hecker
  • Environmental science and pollution research international
  • 2010
VIEW 2 EXCERPTS