Bisphenol A disrupts Notch signaling by inhibiting gamma-secretase activity and causes eye dysplasia of Xenopus laevis.

@article{Baba2009BisphenolAD,
  title={Bisphenol A disrupts Notch signaling by inhibiting gamma-secretase activity and causes eye dysplasia of Xenopus laevis.},
  author={Kazunobu Baba and Kazushi Okada and Tsutomu Kinoshita and Susumu Imaoka},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2009},
  volume={108 2},
  pages={344-55}
}
Bisphenol A (BPA) is being recognized as an endocrine-disrupting chemical (EDC). Recently, several reports indicated that BPA affects the central nervous system (CNS) during embryonic development. However, the molecular mechanism of BPA in the CNS is not well known. Here, we show that BPA affected Notch signaling by inhibiting the activity of the Notch intracellular domain (NICD) cleavage-related enzyme, gamma-secretase (gamma-secretase), at the neurula stage of the Xenopus laevis. BPA caused… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 37 references

P2Y2 nucleotide receptors enhance alpha-secretase-dependent amyloid precursor protein processing.

The Journal of biological chemistry • 2005
View 7 Excerpts
Highly Influenced

Effects of 17beta-estradiol, nonylphenol, and bisphenol-A on developing Xenopus laevis embryos.

General and comparative endocrinology • 2004
View 4 Excerpts
Highly Influenced

Active gamma-secretase complexes contain only one of each component.

The Journal of biological chemistry • 2007
View 3 Excerpts
Highly Influenced

throughout pregnancy

R. H. Duparc, M. Abdouh, +3 authors G. Bernier
2007
View 1 Excerpt
Highly Influenced

Murine neocortical histogenesis is perturbed by prenatal exposure to low doses of Bisphenol A.

Journal of neuroscience research • 2006
View 3 Excerpts
Highly Influenced

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