Bisphenol A delays the perinatal chloride shift in cortical neurons by epigenetic effects on the Kcc2 promoter.

@article{Yeo2013BisphenolAD,
  title={Bisphenol A delays the perinatal chloride shift in cortical neurons by epigenetic effects on the Kcc2 promoter.},
  author={Michele Yeo and Ken Berglund and Michael S Hanna and Junjie U Guo and Jaya Kittur and Mar{\'i}a de Lourdes Torres and Joel Abramowitz and Jorge A. Busciglio and Yuan Gao and Lutz Birnbaumer and Wolfgang B Liedtke},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 11},
  pages={4315-20}
}
Bisphenol A (BPA) is a ubiquitous compound that is emerging as a possible toxicant during embryonic development. BPA has been shown to epigenetically affect the developing nervous system, but the molecular mechanisms are not clear. Here we demonstrate that BPA exposure in culture led to delay in the perinatal chloride shift caused by significant decrease in potassium chloride cotransporter 2 (Kcc2) mRNA expression in developing rat, mouse, and human cortical neurons. Neuronal chloride increased… CONTINUE READING
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