Bisphenol A causes reproductive toxicity, decreases dnmt1 transcription, and reduces global DNA methylation in breeding zebrafish (Danio rerio)

@inproceedings{Laing2016BisphenolAC,
  title={Bisphenol A causes reproductive toxicity, decreases dnmt1 transcription, and reduces global DNA methylation in breeding zebrafish (Danio rerio)},
  author={Lauren V. Laing and Joana Viana and Emma L. Dempster and Maciej Trznadel and L. A. Trunkfield and Tamsyn M Uren Webster and Ronny van Aerle and Gregory C. Paull and Robert J. M. Wilson and Jonathan Mill and Eduarda M. Santos},
  booktitle={Epigenetics},
  year={2016}
}
Bisphenol A (BPA) is a commercially important high production chemical widely used in epoxy resins and polycarbonate plastics, and is ubiquitous in the environment. Previous studies demonstrated that BPA activates estrogenic signaling pathways associated with adverse effects on reproduction in vertebrates and that exposure can induce epigenetic changes. We aimed to investigate the reproductive effects of BPA in a fish model and to document its mechanisms of toxicity. We exposed breeding groups… CONTINUE READING
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