Bisphenol A causes hyperactivity in the rat concomitantly with impairment of tyrosine hydroxylase immunoreactivity.

@article{Ishido2004BisphenolAC,
  title={Bisphenol A causes hyperactivity in the rat concomitantly with impairment of tyrosine hydroxylase immunoreactivity.},
  author={Masami Ishido and Yoshinori Masuo and Manabu Kunimoto and Syuichi Oka and Masatoshi Morita},
  journal={Journal of neuroscience research},
  year={2004},
  volume={76 3},
  pages={423-33}
}
We examined the effects of bisphenol A, an endocrine disruptor, on rat behavioral and cellular responses. Single intracisternal administration of bisphenol A (0.2-20 microg) into 5-day-old male Wistar rats caused significant hyperactivity at 4-5 weeks of age. Rats were about 1.6-fold more active in the nocturnal phase after administration of both 2 and 20 microg of bisphenol A than were control rats. The response was dose-dependent. Based on DNA macroarray analyses of the midbrain, bisphenol A… CONTINUE READING
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