Bisphenol A and its analogues disrupt centrosome cycle and microtubule dynamics in prostate cancer.

  title={Bisphenol A and its analogues disrupt centrosome cycle and microtubule dynamics in prostate cancer.},
  author={Shuk-Mei Ho and Rahul K. Rao and Sarah Q. To and Emma Schoch and Pheruza Tarapore},
  journal={Endocrine-related cancer},
  volume={24 2},
Humans are increasingly exposed to structural analogues of bisphenol A (BPA), as BPA is being replaced by these compounds in BPA-free consumer products. We have previously shown that chronic and developmental exposure to BPA is associated with increased prostate cancer (PCa) risk in human and animal models. Here, we examine whether exposure of PCa cells (LNCaP, C4-2) to low-dose BPA and its structural analogues (BPS, BPF, BPAF, TBBPA, DMBPA and TMBPA) affects centrosome amplification (CA), a… 

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