Bisphenol A Exposure during Adulthood Causes Augmentation of Follicular Atresia and Luteal Regression by Decreasing 17β-Estradiol Synthesis via Downregulation of Aromatase in Rat Ovary

@inproceedings{Lee2013BisphenolAE,
  title={Bisphenol A Exposure during Adulthood Causes Augmentation of Follicular Atresia and Luteal Regression by Decreasing 17β-Estradiol Synthesis via Downregulation of Aromatase in Rat Ovary},
  author={Seung Gee Lee and Ji Young Kim and Jin-Yong Chung and Yoon-Jae Kim and Ji-Eun Park and Seunghoon Oh and Y Yoon and Ki Soo Yoo and Young Hyun Yoo and Jong-Min Kim},
  booktitle={Environmental health perspectives},
  year={2013}
}
BACKGROUND Bisphenol A (BPA) has been detected in human body fluids, such as serum and ovarian follicular fluids. Several reports indicated that BPA exposure is associated with the occurrence of several female reproductive diseases resulting from the disruption of steroid hormone biosynthesis in the adult ovary. OBJECTIVE We hypothesized that long-term exposure to low concentrations of BPA disrupts 17β-estradiol (E2) production in granulosa cells via an alteration of steroidogenic proteins in… CONTINUE READING

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