Bisphenol A (BPA) and its potential role in the pathogenesis of the polycystic ovary syndrome (PCOS)

@article{Rutkowska2014BisphenolA,
  title={Bisphenol A (BPA) and its potential role in the pathogenesis of the polycystic ovary syndrome (PCOS)},
  author={Aleksandra Rutkowska and Dominik Rachoń},
  journal={Gynecological Endocrinology},
  year={2014},
  volume={30},
  pages={260 - 265}
}
Abstract Polycystic ovary syndrome (PCOS) is the most common and the most heterogeneous endocrine disorder in premenopausal women. Apart from signs of hyperandrogenism such as acne, hirsutism and hair loss, women with PCOS usually present with menstrual irregularities and fertility problems.Additionally, they are often characterized by impaired glucose tolerance, which usually leads to the development of type 2 diabetes mellitus (T2DM). This review article describes current and novel approach… 

Review on bisphenol A and the risk of polycystic ovarian syndrome: an insight from endocrine and gene expression

In this review, certain researched effects of BPA are analyzed, while focusing on its ability to alter the expression of various significant genes involved in the pathways and endocrine regulation, whose disruption is commonly associated with the clinical manifestations of PCOS.

Bisphenol-A and polycystic ovary syndrome: a review of the literature

A holistic overview of the available data regarding the possible relation of PCOS with BPA exposure is provided and it is suggested that a correlation between high levels of BPA and the presence ofPCOS may exist.

Bisphenol A impacts hormonal profile in patients with polycystic ovary syndrome but not in healthy women

The purpose of this study was to determine serum bisphenol A (BPA) concentrations using the high-performance liquid chromatography method combined with tandem mass spectrometry in women with

Metabolic and endocrine effects of bisphenol A exposure in market seller women with polycystic ovary syndrome

In BPA-exposed PCOS women, BPA level was higher than healthy women and this difference maybe the cause of significant differences in levels of triglyceride, cholesterol, TSH, and LH:FSH ratio, confirming the potential role of BPA in PCOS pathophysiology.

Impact of endocrine disrupting chemicals (EDCs) on the predisposition of cancer and polycystic ovary syndrome (PCOS): A Note

An outline of research on environmental aspects of EDCs and their effects on human health specially on cancer and PCOS based on evidence from animal and human studies is furnished.

Local effect of bisphenol A on the estradiol synthesis of ovarian granulosa cells from PCOS

Evidence is provided that increased BPA concentration in the follicular fluid of PCOS patients may play an important role in its pathogenesis by attenuating the expression of aromatase in granulosa cells.

The role of stress in PCOS

A literature review, focusing on the most recent data, regarding the multipotent role of stress in the syndrome, found metabolic stress constitutes the pathophysiological heart of the syndrome.

Efficacy of different forms of Guizhi Fuling Wan on reproduction and metabolism in women with polycystic ovary syndrome

This study aims to assess the efficacy and safety of GFW in the treatment of PCOS through a systematic review and meta-analysis, and provide a high-quality synthesis to judge whether GFW is an effective and safe intervention for PCOS.
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