Bisphenol A (BPA) and its potential role in the pathogenesis of the polycystic ovary syndrome (PCOS)

  title={Bisphenol A (BPA) and its potential role in the pathogenesis of the polycystic ovary syndrome (PCOS)},
  author={Aleksandra Rutkowska and Dominik Rachoń},
  journal={Gynecological Endocrinology},
  pages={260 - 265}
Abstract Polycystic ovary syndrome (PCOS) is the most common and the most heterogeneous endocrine disorder in premenopausal women. Apart from signs of hyperandrogenism such as acne, hirsutism and hair loss, women with PCOS usually present with menstrual irregularities and fertility problems.Additionally, they are often characterized by impaired glucose tolerance, which usually leads to the development of type 2 diabetes mellitus (T2DM). This review article describes current and novel approach… 

Review on bisphenol A and the risk of polycystic ovarian syndrome: an insight from endocrine and gene expression

In this review, certain researched effects of BPA are analyzed, while focusing on its ability to alter the expression of various significant genes involved in the pathways and endocrine regulation, whose disruption is commonly associated with the clinical manifestations of PCOS.

Bisphenol-A and polycystic ovary syndrome: a review of the literature

A holistic overview of the available data regarding the possible relation of PCOS with BPA exposure is provided and it is suggested that a correlation between high levels of BPA and the presence ofPCOS may exist.

Bisphenol A impacts hormonal profile in patients with polycystic ovary syndrome but not in healthy women

The purpose of this study was to determine serum bisphenol A (BPA) concentrations using the high-performance liquid chromatography method combined with tandem mass spectrometry in women with

Metabolic and endocrine effects of bisphenol A exposure in market seller women with polycystic ovary syndrome

In BPA-exposed PCOS women, BPA level was higher than healthy women and this difference maybe the cause of significant differences in levels of triglyceride, cholesterol, TSH, and LH:FSH ratio, confirming the potential role of BPA in PCOS pathophysiology.

Local effect of bisphenol A on the estradiol synthesis of ovarian granulosa cells from PCOS

Evidence is provided that increased BPA concentration in the follicular fluid of PCOS patients may play an important role in its pathogenesis by attenuating the expression of aromatase in granulosa cells.

The role of stress in PCOS

A literature review, focusing on the most recent data, regarding the multipotent role of stress in the syndrome, found metabolic stress constitutes the pathophysiological heart of the syndrome.

Efficacy of different forms of Guizhi Fuling Wan on reproduction and metabolism in women with polycystic ovary syndrome

This study aims to assess the efficacy and safety of GFW in the treatment of PCOS through a systematic review and meta-analysis, and provide a high-quality synthesis to judge whether GFW is an effective and safe intervention for PCOS.

An update on polycystic ovary syndrome: A review of the current state of knowledge in diagnosis, genetic etiology, and emerging treatment options

The most recent research done to establish relationships between different gene polymorphisms with polycystic ovary syndrome in various populations along with the underestimated impact of environmental factors like endocrine-disrupting chemicals on the reproductive health of these women are looked at.



Endocrine disruptors and polycystic ovary syndrome (PCOS): elevated serum levels of bisphenol A in women with PCOS.

Higher BPA levels inPCOS women compared to controls and a statistically significant positive association between androgens and BPA point to a potential role of this endocrine disruptor in PCOS pathophysiology.

A molecular mechanism underlying ovarian dysfunction of polycystic ovary syndrome: hyperandrogenism induces epigenetic alterations in the granulosa cells

Hyperandrogenism induces the epigenetic alterations of PPARG1, NCOR1, and HDAC3 in GCs, which are involved in the ovarian dysfunction of polycystic ovary syndrome (PCOS) women, consistent with the results from humans.

A survey of the polycystic ovary syndrome in the Greek island of Lesbos: hormonal and metabolic profile.

Polycystic ovary syndrome appears to be a particularly common endocrine disorder in the Greek population under study and it is associated with certain metabolic abnormalities, suggesting that the severity of the fasting hyperinsulinemia isassociated with the severity with the clinical phenotype of hyperandrogenism independently of obesity.

Bisphenol A in polycystic ovary syndrome and its association with liver–spleen axis

Increased spleen volume, a reliable and stable index of chronic inflammation, was strictly associated with the severity of hepatic steatosis (HS) in obese subjects, determining the so‐called liver–spleen axis.

The prevalence and features of the polycystic ovary syndrome in an unselected population.

Data from a large representative unselected population support the concept that PCOS is the most common endocrine abnormality of reproductive-aged women in the United States.

Genetics of polycystic ovary syndrome: searching for the way out of the labyrinth.

Focused research in identification of candidate genes may provide valuable information and shed some light on the way out of the genomic labyrinth, elucidating the underlying pathophysiology and aiming at a more efficient therapeutic approach of this complicated endocrine disorder.

A meta-analysis of pregnancy outcomes in women with polycystic ovary syndrome.

In conclusion, women with PCOS are at increased risk of pregnancy and neonatal complications and pre-pregnancy, antenatal and intrapartum care should be aimed at reducing these risks.

Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis.

  • A. Dunaif
  • Biology, Medicine
    Endocrine reviews
  • 1997
Since PCOS usually has a menarchal age of onset, this makes it a particularly appropriate disorder in which to examine the ontogeny of defects in carbohydrate metabolism and for ascertaining large three-generation kindreds for positional cloning studies to identify NIDDM genes.

Neonatal Exposure to Bisphenol A and Reproductive and Endocrine Alterations Resembling the Polycystic Ovarian Syndrome in Adult Rats

Exposure to high doses of BPA during the period of brain sexual differentiation altered the hypothalamic–pituitary–gonadal axis in female Sprague-Dawley rats, and these results have the potential to link neonatal exposure to high dose BPA in rats with the development of polycystic ovarian syndrome.

High plasma concentrations of di-(2-ethylhexyl)-phthalate in women with endometriosis.

The present findings showed for the first time an association between DEHP plasma concentrations and endometriosis, suggesting a possible role for phthalate esters in the pathogenesis.