Bisphenol A: invisible pollution

  title={Bisphenol A: invisible pollution},
  author={Tricia Groff},
  journal={Current Opinion in Pediatrics},
  • T. Groff
  • Published 1 August 2010
  • Medicine
  • Current Opinion in Pediatrics
Purpose of review Bisphenol A (BPA) is a high volume chemical used in a wide variety of products, including plastic bottles and canned goods. Based on widespread human exposure and endocrine effects observed first in animal studies and now in humans, this chemical is being extensively studied. Most physicians have not had formal teaching regarding human risks from environmental exposures such as BPA. This article aims to provide: 1) a basis for learning about BPA as an environmental exposure… 

Human exposures to bisphenol A: mismatches between data and assumptions

Evidence is addressed that challenges the assumption that humans metabolize BPA rapidly enough to result in undetectable levels in blood and therefore it is determined that there is a possibility of harm from current exposure levels.

Exposure assessment of endocrine disruptors in bottled drinking water of Lebanon

Assessment of BPA human exposure and associated health risks from drinking water in Lebanese finds estimated exposure levels are below the reference dose (RfD), but further studies are needed to quantitate exposure from various sources and to investigate EDR contribution to existing epidemics in the country.

Bisphenol A exposure assessment from olive oil consumption

The estimated exposure to BPA levels in olive oil samples stored in plastic vs. non-plastic packaging was 1.38% of the EFSA tolerable daily intake, hence there are no concerns about potential health risks from olive oil consumption.

Bisphenol A: Human exposure and neurobehavior.

Exposure to Bisphenol A From Drinking Canned Beverages Increases Blood Pressure: Randomized Crossover Trial

It is demonstrated that consuming canned beverage and consequent increase of BPA exposure increase blood pressure acutely and the parameters of the heart rate variability did not show statistically significant differences.

Occurrence of Bisphenol A in Indoor Dust from Two Locations in the Eastern United States and Implications for Human Exposures

The contribution of dust to total human BPA intake was estimated to be <1%, however, suggesting that dietary intake is the predominant source of exposures in humans.

Protection against Neurobehavioral Changes Induced by Bisphenol A during Development in Rats

Zn and/or Se can protect against BPA-induced alterations, and co-administration with BPA improved physical and neurobehavioral development as well as performance of pups in the behavioural experiments.

The effects of postnatal exposure to low-dose bisphenol-A on activity-dependent plasticity in the mouse sensory cortex

Exposure to very low levels of BPA during a critical period of brain development can have profound consequences for the normal wiring of sensory circuits and their plasticity later in life.

Associations of Bisphenol A Exposure With Heart Rate Variability and Blood Pressure

It is observed that urinary BPA was associated negatively with the root mean square of successive differences for heart rate and positively with blood pressure and the odds ratio of showing hypertension was increased.

Oestrogenic Endocrine Disruptors in the Placenta and the Fetus

The mechanism and detection methods of estrogenic endocrine disruptors, such as bisphenol A (BPA), organochlorine pesticides (OCPs), diethylstilbestrol (DES) and phthalates (PAEs), and their effects on placenta and fetal health are elaborated in order to raise concerns about the proper use of products containing EDCs during pregnancy and provide a reference for human health.



Bisphenol A and risk of metabolic disorders.

The study by Lang et al, while preliminary with regard to these diseases in humans, should spur US regulatory agencies to follow the recent action taken by Canadian regulatory agencies, which have declared BPA a “toxic chemical” requiring aggressive action to limit human and environmental exposures.

Bisphenol A: Perinatal exposure and body weight

Bisphenol-A and the great divide: a review of controversies in the field of endocrine disruption.

This review has covered the above-mentioned controversies plus six additional issues that have divided scientists in the field of BPA research, namely: mechanisms of bisphenol-A action; levels of human exposure; 3) routes of human Exposure; 4) pharmacokinetic models of Bpa metabolism; 5) effects of B PA on exposed animals; and 6) links between BPA and cancer.

Toxic effects of low doses of Bisphenol-A on human placental cells.

Bisphenol A: Where to Now?

  • J. Bucher
  • Biology
    Environmental health perspectives
  • 2009
The NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Bisphenol A identified evidence from experimental animal studies that raised “some concern” that current levels of exposure to human fetuses, infants, and children may result in developmental changes in the prostate gland and brain and diminish sexually dimorphic behaviors.

Endocrine-disrupting chemicals probed as potential pathways to illness.

There is now greater recognition that the developing organism may be especially vulnerable to endocrinedisrupting chemicals because of such factors as deficiencies in DNA repair mechanisms, detoxification enzymes that are not completely functional, and a blood-brain barrier that is still being formed.

Large effects from small exposures. III. Endocrine mechanisms mediating effects of bisphenol A at levels of human exposure.

Concern with human exposure to BPA derives from identification of molecular mechanisms mediating effects in human and animal tissues at very low doses, in vivo effects in experimental animals caused by low doses within the range of human exposure, and widespread human Exposure to levels of BPA that cause adverse effects in animals.

An Extensive New Literature Concerning Low-Dose Effects of Bisphenol A Shows the Need for a New Risk Assessment

It is proposed that a new risk assessment for BPA is needed based on the extensive new literature reporting adverse effects in animals at doses below the current reference dose, and the high rate of leaching of BPA from food and beverage containers, leading to widespread human exposure.