Bisphenol A: invisible pollution

@article{Groff2010BisphenolAI,
  title={Bisphenol A: invisible pollution},
  author={Tricia Groff},
  journal={Current Opinion in Pediatrics},
  year={2010},
  volume={22},
  pages={524–529}
}
  • T. Groff
  • Published 2010
  • Medicine
  • Current Opinion in Pediatrics
Purpose of review Bisphenol A (BPA) is a high volume chemical used in a wide variety of products, including plastic bottles and canned goods. Based on widespread human exposure and endocrine effects observed first in animal studies and now in humans, this chemical is being extensively studied. Most physicians have not had formal teaching regarding human risks from environmental exposures such as BPA. This article aims to provide: 1) a basis for learning about BPA as an environmental exposure… Expand
Human exposures to bisphenol A: mismatches between data and assumptions
TLDR
Evidence is addressed that challenges the assumption that humans metabolize BPA rapidly enough to result in undetectable levels in blood and therefore it is determined that there is a possibility of harm from current exposure levels. Expand
Exposure assessment of endocrine disruptors in bottled drinking water of Lebanon
TLDR
Assessment of BPA human exposure and associated health risks from drinking water in Lebanese finds estimated exposure levels are below the reference dose (RfD), but further studies are needed to quantitate exposure from various sources and to investigate EDR contribution to existing epidemics in the country. Expand
Bisphenol A exposure assessment from olive oil consumption
TLDR
The estimated exposure to BPA levels in olive oil samples stored in plastic vs. non-plastic packaging was 1.38% of the EFSA tolerable daily intake, hence there are no concerns about potential health risks from olive oil consumption. Expand
Bisphenol A: Human exposure and neurobehavior.
TLDR
The results suggest that prenatal BPA exposure may have a negative impact on neurobehavioral functioning in children and that the effects may be sex-dependent, and it is desirable to inform women planning or undergoing pregnancy about measures to reduce or avoid exposure to BPA. Expand
Exposure to Bisphenol A From Drinking Canned Beverages Increases Blood Pressure: Randomized Crossover Trial
TLDR
It is demonstrated that consuming canned beverage and consequent increase of BPA exposure increase blood pressure acutely and the parameters of the heart rate variability did not show statistically significant differences. Expand
Occurrence of Bisphenol A in Indoor Dust from Two Locations in the Eastern United States and Implications for Human Exposures
  • S. Loganathan, K. Kannan
  • Environmental Science, Medicine
  • Archives of environmental contamination and toxicology
  • 2011
TLDR
The contribution of dust to total human BPA intake was estimated to be <1%, however, suggesting that dietary intake is the predominant source of exposures in humans. Expand
Protection against Neurobehavioral Changes Induced by Bisphenol A during Development in Rats
TLDR
Zn and/or Se can protect against BPA-induced alterations, and co-administration with BPA improved physical and neurobehavioral development as well as performance of pups in the behavioural experiments. Expand
The effects of postnatal exposure to low-dose bisphenol-A on activity-dependent plasticity in the mouse sensory cortex
TLDR
Exposure to very low levels of BPA during a critical period of brain development can have profound consequences for the normal wiring of sensory circuits and their plasticity later in life. Expand
Associations of Bisphenol A Exposure With Heart Rate Variability and Blood Pressure
TLDR
It is observed that urinary BPA was associated negatively with the root mean square of successive differences for heart rate and positively with blood pressure and the odds ratio of showing hypertension was increased. Expand
Oestrogenic Endocrine Disruptors in the Placenta and the Fetus
TLDR
The mechanism and detection methods of estrogenic endocrine disruptors, such as bisphenol A (BPA), organochlorine pesticides (OCPs), diethylstilbestrol (DES) and phthalates (PAEs), and their effects on placenta and fetal health are elaborated in order to raise concerns about the proper use of products containing EDCs during pregnancy and provide a reference for human health. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 53 REFERENCES
Human exposure to bisphenol A (BPA).
TLDR
The reported levels of BPA in human fluids are higher than the BPA concentrations reported to stimulate molecular endpoints in vitro and appear to be within an order of magnitude of the levels needed to induce effects in animal models. Expand
Bisphenol A and risk of metabolic disorders.
TLDR
The study by Lang et al, while preliminary with regard to these diseases in humans, should spur US regulatory agencies to follow the recent action taken by Canadian regulatory agencies, which have declared BPA a “toxic chemical” requiring aggressive action to limit human and environmental exposures. Expand
Bisphenol A: Perinatal exposure and body weight
  • B. Rubin, A. Soto
  • Chemistry, Medicine
  • Molecular and Cellular Endocrinology
  • 2009
TLDR
The potential for BPA to influence body weight is suggested by in vitro studies demonstrating effects of BPA on adipocyte differentiation, lipid accumulation, glucose transport and adiponectin secretion, and possible targets of B PA action are discussed. Expand
Bisphenol-A and the great divide: a review of controversies in the field of endocrine disruption.
TLDR
This review has covered the above-mentioned controversies plus six additional issues that have divided scientists in the field of BPA research, namely: mechanisms of bisphenol-A action; levels of human exposure; 3) routes of human Exposure; 4) pharmacokinetic models of Bpa metabolism; 5) effects of B PA on exposed animals; and 6) links between BPA and cancer. Expand
Polycarbonate Plastics and Human BPA Exposure: Urinary Levels Rise with Use of Drinking Bottles
  • V. McGovern
  • Medicine, Biology
  • Environmental health perspectives
  • 2009
TLDR
A new study of human exposure to BPA from drinking containers shows that study participants’ urinary concentrations of the molecule increased by two-thirds after they used polycarbonate drinking bottles for 1 week, and predicts higher urinary BPA concentrations would result from drinking hot beverages stored in the same bottles. Expand
In vivo effects of bisphenol A in laboratory rodent studies.
TLDR
It is likely, but requiring further confirmation, that adult exposure to BPA affects the brain, the female reproductive system, and the immune system and that developmental effects occur in theFemale reproductive system. Expand
Toxic effects of low doses of Bisphenol-A on human placental cells.
TLDR
The findings suggest that exposure of placental cells to low doses of BPA may cause detrimental effects, leading in vivo to adverse pregnancy outcomes such as preeclampsia, intrauterine growth restriction, prematurity and pregnancy loss. Expand
Bisphenol A: Where to Now?
  • J. Bucher
  • Medicine
  • Environmental health perspectives
  • 2009
TLDR
The NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Bisphenol A identified evidence from experimental animal studies that raised “some concern” that current levels of exposure to human fetuses, infants, and children may result in developmental changes in the prostate gland and brain and diminish sexually dimorphic behaviors. Expand
Endocrine-disrupting chemicals probed as potential pathways to illness.
TLDR
There is now greater recognition that the developing organism may be especially vulnerable to endocrinedisrupting chemicals because of such factors as deficiencies in DNA repair mechanisms, detoxification enzymes that are not completely functional, and a blood-brain barrier that is still being formed. Expand
Large effects from small exposures. III. Endocrine mechanisms mediating effects of bisphenol A at levels of human exposure.
TLDR
Concern with human exposure to BPA derives from identification of molecular mechanisms mediating effects in human and animal tissues at very low doses, in vivo effects in experimental animals caused by low doses within the range of human exposure, and widespread human Exposure to levels of BPA that cause adverse effects in animals. Expand
...
1
2
3
4
5
...