Bisphenol A: An endocrine disruptor with widespread exposure and multiple effects

@article{Rubin2011BisphenolAA,
  title={Bisphenol A: An endocrine disruptor with widespread exposure and multiple effects},
  author={Beverly S. Rubin},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={2011},
  volume={127},
  pages={27-34}
}
  • B. Rubin
  • Published 1 October 2011
  • Biology
  • The Journal of Steroid Biochemistry and Molecular Biology
Human Health Effects of Bisphenol A
TLDR
This chapter reviews the latest research on BPA, focusing on human exposure, discussions of biomonitoring studies and toxicokinetic models, human health effects, and research needs, and includes illustrative examples of animal models that address whether BPA-exposure is associated with changes in certain health endpoints.
Bisphenol A: Food Exposure and Impact on Human Health.
TLDR
This review contains the most recent in vitro and in vivo studies on BPA toxicity and its harmful effects on health, and it intends to address human exposure to BPA, namely through dietary exposure and its impact on human health.
Current State of Use and the Risks of Bisphenols: A Minireview
Bisphenol A (BPA), known as a typical endocrine disruptor, has been used commercially and widely for plastics and epoxy resins. BPA-based plastic is used extensively for the production of water
A review on sources and health impacts of bisphenol A
TLDR
In-depth studies are needed to understand the fate of these compounds particularly in the developing nations and the associated adverse health impacts of BPA due to prolonged exposure.
Prenatal exposure to bisphenols and parabens and impacts on human physiology.
TLDR
Taking into account the widespread occurrence of various EDs and the potential multiplicity of their effects, doses of EDs currently considered safe may not actually be as safe as they appear, especially during pregnancy.
Bisphenol a: a model endocrine disrupting chemical with a new potential mechanism of action.
TLDR
For many human health endpoints, there is strong evidence to support the hypothesis that EDCs, within the range of current human exposure, are having adverse health impacts on the general population.
Occupational Exposure to Bisphenol A (BPA): A Reality That Still Needs to Be Unveiled
TLDR
A review of the literature on BPA occupational exposure and associated health effects raises awareness of the dramatic and consistent increase in the production and exposure of BPA and creates urgency to assess the actual exposure of workers to this xenoestrogen and to evaluate potential associated adverse health effects.
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References

SHOWING 1-10 OF 116 REFERENCES
Large effects from small exposures. III. Endocrine mechanisms mediating effects of bisphenol A at levels of human exposure.
TLDR
Concern with human exposure to BPA derives from identification of molecular mechanisms mediating effects in human and animal tissues at very low doses, in vivo effects in experimental animals caused by low doses within the range of human exposure, and widespread human Exposure to levels of BPA that cause adverse effects in animals.
Bisphenol A: Perinatal exposure and body weight
Perinatal exposure to bisphenol-a and the development of metabolic syndrome in CD-1 mice.
TLDR
This study tested the hypothesis that perinatal exposure to an ecologically relevant dose of BPA results in increased susceptibility to high-fat diet-induced obesity and glucose intolerance in adult CD-1 mice, and found that weanling mice exposed to BPA during gestation and lactation are heavier compared with control mice.
Urinary, Circulating, and Tissue Biomonitoring Studies Indicate Widespread Exposure to Bisphenol A
TLDR
Available data from biomonitoring studies clearly indicate that the general population is exposed to BPA and is at risk from internal exposure to unconjugated BPA.
Ubiquity of bisphenol A in the atmosphere.
Perinatal exposure to low doses of bisphenol A affects body weight, patterns of estrous cyclicity, and plasma LH levels.
TLDR
Data indicate an increased sensitivity to BPA during the perinatal period and suggest the need for careful evaluation of the current levels of exposure to this compound.
Bisphenol-A and the great divide: a review of controversies in the field of endocrine disruption.
TLDR
This review has covered the above-mentioned controversies plus six additional issues that have divided scientists in the field of BPA research, namely: mechanisms of bisphenol-A action; levels of human exposure; 3) routes of human Exposure; 4) pharmacokinetic models of Bpa metabolism; 5) effects of B PA on exposed animals; and 6) links between BPA and cancer.
Bisphenol-A, an environmental contaminant that acts as a thyroid hormone receptor antagonist in vitro, increases serum thyroxine, and alters RC3/neurogranin expression in the developing rat brain.
TLDR
It is reported that dietary exposure to BPA of Sprague Dawley rats during pregnancy and lactation causes an increase in serum total T4 in pups on postnatal d 15, but serum TSH was not different from controls, suggesting that BPA acts as a TH antagonist on the beta-TR, which mediates the negative feedback effect of TH on the pituitary gland.
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