Bispecific single chain molecules (Janusins) target cytotoxic lymphocytes on HIV infected cells.

@article{Traunecker1991BispecificSC,
  title={Bispecific single chain molecules (Janusins) target cytotoxic lymphocytes on HIV infected cells.},
  author={Andr{\'e} Traunecker and Antonio Lanzavecchia and Klaus Dr. Karjalainen},
  journal={The EMBO journal},
  year={1991},
  volume={10 12},
  pages={
          3655-9
        }
}
The human immunodeficiency virus type 1 (HIV-1) uses cell surface CD4 as a receptor to infect susceptible cells. Therefore, different forms of soluble CD4 (sCD4) molecules have been developed recently for potential therapeutic purposes. Here we describe a novel design of sCD4 molecules which exploit cytotoxic T cells as their effector function. The principle of bispecific antibodies was exploited and further developed to create new bispecific reagents which could retarget cytotoxic T cells of… CONTINUE READING
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