Bisoxazolidine-catalyzed enantioselective Reformatsky reaction.


A readily available chiral bisoxazolidine catalyzes the asymmetric Reformatsky reaction between ethyl iodoacetate and aldehydes. In the presence of 10 mol % of the ligand, dimethylzinc, and air, this method produces ethyl 3-hydroxy-3-(4-aryl)propanoates in high yields and in 75 to 80% ee at room temperature within 1 h. In contrast to aromatic substrates… (More)
DOI: 10.1021/jo200774e


Cite this paper

@article{Wolf2011BisoxazolidinecatalyzedER, title={Bisoxazolidine-catalyzed enantioselective Reformatsky reaction.}, author={Christian Wolf and Max Moskowitz}, journal={The Journal of organic chemistry}, year={2011}, volume={76 15}, pages={6372-6} }