Bisoprolol vs. carvedilol in elderly patients with heart failure: rationale and design of the CIBIS-ELD trial

  title={Bisoprolol vs. carvedilol in elderly patients with heart failure: rationale and design of the CIBIS-ELD trial},
  author={Hans-Dirk D{\"u}ngen and Svetlana R. Apostolovic and Simone Inkrot and Elvis Tahirovi{\'c} and Florian Krackhardt and Milan Pavlovi{\'c} and Biljana Putnikovi{\'c} and Mitja Lainscak and Goetz Gelbrich and Frank T Edelmann and Rolf Wachter and Thomas Eschenhagen and Finn Waagstein and Ferenc Follath and Mathias Rauchhaus and Wilhelm Haverkamp and K Osterziel and Rainer Dietz},
  journal={Clinical Research in Cardiology},
Chronic heart failure (CHF) is a widespread disease with severe quality of life impairment and a poor prognosis. Beta-blockers are the mainstay of CHF therapy; yet they are under-prescribed and under-dosed in clinical practice. This is particularly evident in elderly patients, which may be due to a fear of side-effects or intolerance. Beta-blockers have further not been adequately tested in patients with diastolic CHF, which is particularly common in elderly patients. Finally, comparative data… CONTINUE READING


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