Bisoprolol responses (PK/PD) in hypertensive patients: A cytochrome P450 (CYP) 2D6 targeted polymorphism study

@article{Alkreathy2020BisoprololR,
  title={Bisoprolol responses (PK/PD) in hypertensive patients: A cytochrome P450 (CYP) 2D6 targeted polymorphism study},
  author={Huda Mohammed Alkreathy and Khlood Mohammed Eid Alsayyid and Jumana Y. Alaama and Kamal Al Ghalayini and S. Karim and A. Esmat and Z. A. Damanhouri},
  journal={Saudi Journal of Biological Sciences},
  year={2020},
  volume={27},
  pages={2727 - 2732}
}
Background Bisoprolol is an effective β1-adrenergic blocker, an inter-individual genetic variability was recorded in its response. This study aimed at investigating the association of CYP2D6*2A (rs1080985) and CYP2D6*10 (rs1065852) single-nucleotide polymorphism (SNP) with Bisoprolol response in cardiac patients attending King Abdulaziz University Hospital, Jeddah, Kingdom of Saudi Arabia. Patients and methods In the study, 107 patients were enrolled. Five mL of venous blood was collected from… Expand

Figures and Tables from this paper

References

SHOWING 1-10 OF 29 REFERENCES
Pharmacokinetic variability of routinely administered bisoprolol in middle-aged and elderly Japanese patients.
Bioequivalence study of 2.5 mg film-coated bisoprolol tablets in healthy volunteers.
Cardiovascular pharmacogenetics.
...
1
2
3
...