Bismuth-norfloxacin complex: synthesis, physicochemical and antimicrobial evaluation.

  title={Bismuth-norfloxacin complex: synthesis, physicochemical and antimicrobial evaluation.},
  author={Anwar Rafique Shaikh and Rajani Giridhar and Mange Ram Yadav},
  journal={International journal of pharmaceutics},
  volume={332 1-2},
Norfloxacin is a fluoroquinolone antibacterial agent which is active against various Gram-positive as well as Gram-negative microorganisms. Presence of metal ions considerably alters the activity of fluoroquinolones against potentially susceptible bacteria. As bismuth is known to possess a good antibacterial activity, bismuth complex of norfloxacin was prepared by reacting bismuth citrate with aqueous solution of norfloxacin. The structure of the bismuth-norfloxacin complex (BNC) was confirmed… CONTINUE READING
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