Bismuth biokinetics and kidney histopathology after bismuth overdose in rats

@article{Leussink2000BismuthBA,
  title={Bismuth biokinetics and kidney histopathology after bismuth overdose in rats},
  author={Berend T. Leussink and Anja Slikkerveer and Walter J. J. Krauwinkel and Gijsbert B. van der Voet and Emile de Heer and Frederik A. de Wolff and Jan Anthonie Bruijn},
  journal={Archives of Toxicology},
  year={2000},
  volume={74},
  pages={349-355}
}
Bismuth induced nephrotoxicity has been reported to occur after acute overdoses of Bi-containing therapeutic drugs. We studied the development of bismuth induced nephropathy and bismuth biokinetics in rats. Bismuth nephropathy was induced in 33 young adult female Wistar rats weighing ca. 175 g by feeding them a single overdose of colloidal bismuth subcitrate containing 3.0 mmol Bi/kg at (t=0). Control animals (n=7) were fed the vehicle only. The animals were sacrificed after 1–48 h. Plasma… CONTINUE READING
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