Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications

  title={Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications},
  author={Felix Krueger and Simon R. Andrews},
SUMMARY A combination of bisulfite treatment of DNA and high-throughput sequencing (BS-Seq) can capture a snapshot of a cell's epigenomic state by revealing its genome-wide cytosine methylation at single base resolution. Bismark is a flexible tool for the time-efficient analysis of BS-Seq data which performs both read mapping and methylation calling in a single convenient step. Its output discriminates between cytosines in CpG, CHG and CHH context and enables bench scientists to visualize and… CONTINUE READING
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