Biscembranoids and Cembranoids from the Soft Coral Sarcophyton elegans

Abstract

Two novel biscembranoids, sarelengans A and B (1 and 2), five new cembranoids, sarelengans C-G (3-7), along with two known cembranoids (8 and 9) were isolated from the South China Sea soft coral Sarcophyton elegans. Their structures were determined by spectroscopic and chemical methods, and those of 1, 4, 5, and 6 were confirmed by single crystal X-ray diffraction. Compounds 1 and 2 represent the first example of biscembranoids featuring a trans-fused A/B-ring conjunction between the two cembranoid units. Their unique structures may shed light on an unusual biosynthetic pathway involving a cembranoid-∆⁸ rather than the normal cembranoid-∆¹ unit in the endo-Diels-Alder cycloaddition. Compounds 2 and 3 exhibited potential inhibitory effects on nitric oxide production in RAW 264.7 macrophages, with IC50 values being at 18.2 and 32.5 μM, respectively.

DOI: 10.3390/md15040085

Cite this paper

@inproceedings{Li2017BiscembranoidsAC, title={Biscembranoids and Cembranoids from the Soft Coral Sarcophyton elegans}, author={Wei Li and Yi-Hong Zou and Man-Xi Ge and Lan-lan Lou and Yun-Shao Xu and Abrar Ahmed and Yun-Yun Chen and Jun-sheng Zhang and Guihua Tang and Sheng Yin}, booktitle={Marine drugs}, year={2017} }