Bisalbuminuria in an adult with bisalbuminemia and nephrotic syndrome.

  title={Bisalbuminuria in an adult with bisalbuminemia and nephrotic syndrome.},
  author={M. Hoang and L. Baskin and F. Wians},
  journal={Clinica chimica acta; international journal of clinical chemistry},
  volume={284 1},
  • M. Hoang, L. Baskin, F. Wians
  • Published 1999
  • Chemistry, Medicine
  • Clinica chimica acta; international journal of clinical chemistry
Bisalbuminemia (or alloalbuminemia) is a relatively rare hereditary or acquired condition characterized by the presence of two distinct albumin bands, or, less commonly, a single widened albumin band, after agarose gel electrophoresis of serum. Bisalbumins are caused by point- or chain-mutations that occur with a population frequency of 1:10,000 to 1:1000. Although no adverse clinical effects have been attributed to bisalbumins, some albumin variants have altered affinity for steroid hormones… Expand
Inherited bisalbuminemia with benign monoclonal gammopathy detected by capillary but not agarose gel electrophoresis.
An acquired or transient form has been described that usually has a faster mobility, and may be seen in patients who receive large amounts of β-lactam antibiotics or have pancreatic diseases, usually complicated by a ruptured false cyst. Expand
Bisalbuminemia in chronic kidney disease
The finding of bisalbuminemia did not influence the diagnosis, management, course, or prognosis of chronic kidney disease and the possibility that some physiologic or pharmacologic substances may not bind to abnormal albumin variants as well as they bind to normal albumin should not be discounted. Expand
Bisalbuminemia in an African Male with Sickle Cell Disease
The aim of this case report is to discuss the clinical significance of bisalbuminemia in a 58-year-old African male with sickle cell anemia. Expand
A Case of Bisalbuminemia Associated with Nonsteroidal Anti-Inflammatory Drug-Induced Nephrotic Syndrome
The hereditary form is permanent whereas the acquired bisalbuminemia is transient and usually observed during treatment with beta-lactams, acute pancreatitis, rupture of pancreatic pseudocysts andExpand
Bisalbuminemia: Lack of Association with Monoclonal Gammopathy and Value-Justification for Reporting in Serum Protein Electrophoresis
Bisalbuminemia, genetic or acquired, is a rare incidental SPE finding that is not associated with MG, and hence value justification for its reporting in SPE is provided. Expand
[Clinical characteristics and ALB gene mutation analysis of Korean patients with bisalbuminemia].
The ALB gene analysis with 3D modeling is useful for determining the nature of bisalbuminemia and for predicting the effects on the albumin-binding affinity of other biochemical compounds. Expand
Detection of hereditary bisalbuminemia in a Greek family by capillary zone electrophoresis.
A case of a family, four members of which suffer from hereditary bisalbuminemia, which was initially detected in a 29-year old male, by serum protein electrophoresis (SPE), during the investigation for possible multiple sclerosis. Expand
Human serum albumin isoforms: genetic and molecular aspects and functional consequences.
Alloalbumins do not seem to be associated with disease, they can be used as markers of migration and provide a model for study of neutral molecular evolution, and can also give valuable molecular information about albumins binding sites, antioxidant and enzymatic properties, as well as stability. Expand
Bisalbuminemia accompanying bisalbuminuria detected in capillary electrophoresis, not in gel electrophoresis
This research presents a novel and scalable approach that allows for real-time measurement of the response of the immune system to chemotherapy-like drugs. Expand
On the path to evidence-based reporting of serum protein electrophoresis patterns in the absence of a discernible monoclonal protein - A critical review of literature and practice suggestions.
• Reporting SPE patterns and their implied clinical conditions that may or may not be related to monoclonal gammapthy is controversial;


[Nephrotic syndrome].
The nephrotic syndrome is defined by a urinary protein level exceeding 3.5 g per 1.73 m2 of body-surface area per day, which is arbitrary and special significance should not be given to the . Expand
Transient "bisalmuminemia" induced by drugs.
In vitro experi- ments using normal sera, sera from patients with known inherited albumin variants, and purified albumin solutions show that this phenomenon is related to the concen- tration of the drug in the serum and that the abnormal component is the result of binding of theDrug to albumin. Expand
Structural or functional heterogeneity of normal human serum albumin, allo albumin, bisalbumin.
A comparative isoelectric focusing study of electrophoretically normal and abnormal albumins agrees with the hypothesis that the heterogeneity depends on the structure and the carrier function of albumin. Expand
Amino acid substitutions in inherited albumin variants from Amerindian and Japanese populations.
We report an effort to determine the basis for the altered migration of seven inherited albumin variants detected by one-dimensional electrophoresis in population surveys involving tribal AmerindiansExpand
Bisalbumin (Fast and Slow Type) Induced by Human Pancreatic Juice
It is demonstrated that human pancreatic juice can produce fast-and slow-type albumins by proteolytic enzymes, and they are seen in patients with pancreatic ascites. Expand
Binding of warfarin, salicylate, and diazepam to genetic variants of human serum albumin with known mutations.
Investigating the interactions between the strongly bound drugs warfarin, salicylate, and diazepam and five structurally characterized genetic variants of the protein found conformational changes in the 313-365 region of the proteins are the main cause for diminished binding of these diverse ligands. Expand
Hormone binding to natural mutants of human serum albumin.
The experimental findings suggest different high-affinity sites for the four hormones are apparently bound within the middle third (domain II) of the protein molecule. Expand
Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge.
A method for estimating the cholesterol content of the serum low-density lipoprotein fraction (Sf0-20) is presented and comparison of this suggested procedure with the more direct procedure, in which the ultracentrifuge is used, yielded correlation coefficients of .94 to .99. Expand