Bisacylphosphonates Inhibit Hydroxyapatite Formation and Dissolution in Vitro and Dystrophic Calcification in Vivo

@article{Golomb1992BisacylphosphonatesIH,
  title={Bisacylphosphonates Inhibit Hydroxyapatite Formation and Dissolution in Vitro and Dystrophic Calcification in Vivo},
  author={Gershon Golomb and Ada Schlossman and Hanan Saadeh and Matilda Levi and J. M. E. van Gelder and Eli Breuer},
  journal={Pharmaceutical Research},
  year={1992},
  volume={9},
  pages={143-148}
}
Some geminal bisphosphonates are used clinically for a number of important bone/calcium related diseases; however, side effects and lack of selectivity impede their wide use. This work reports the synthesis and evaluation of bisacylphosphonates (e.g., adipoyl- and suberoylbisphosphonate). These compounds were found to inhibit significantly hydroxyapatite… CONTINUE READING