Bisabolol ameliorates cisplatin-induced nephrotoxicity in rats

  title={Bisabolol ameliorates cisplatin-induced nephrotoxicity in rats},
  author={Moghdeh Mansoori and N Al Shamri and N Al Kendi and Milad Jaberi and Azimullah Sheikh and Naheed Amir and N Nalin and Shreesh Kumar Ojha},
Introduction: Cisplatin (CSP) is a commonly used anticancer drug, but its notable side-effect (nephrotoxicity) limits its use in the clinic. Bisabolol (BSB), a natural monocyclic sesquiterpene alcohol, has garnered attention in recent years because of its antioxidant, anti-inflammatory and antitumorigenic activities. Objectives: To investigate whether BSB can prevent the nephrotoxic effect of CSP in a clinically relevant murine model, and determine the mechanisms involved. Material and methods… 
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