Bis-tetrahydroisoquinoline derivatives: structure analysis of the three stereoisomers of 1,1'-(propane-1,3-diyl)-bis-(6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline).

@article{Wouters2010BistetrahydroisoquinolineDS,
  title={Bis-tetrahydroisoquinoline derivatives: structure analysis of the three stereoisomers of 1,1'-(propane-1,3-diyl)-bis-(6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline).},
  author={Johan Wouters and Kossay Elasaad and Bernadette Norberg and Amaury Graulich and Jean-François Li{\'e}geois},
  journal={European journal of medicinal chemistry},
  year={2010},
  volume={45 7},
  pages={
          3240-4
        }
}
Crystal structure of the three stereoisomers of 1,1'-(propane-1,3-diyl)-bis-(6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline) hydrochloride after resolution by semi-preparative chiral HPLC establishes the absolute configuration and conformation. 
5 Citations
Structural analysis of some bis-(8-isopropyl-isoquinolinium) derivatives reveals a preferential folded conformation leading to a stereoselective attack by sodium borohydride
Abstract Reduction of symmetrical bis-isoquinolinium derivatives with sodium borohydride generates normally a mixture of three 1,2,3,4-tetrahydroisoquinoline stereoisomers. In a series of 8-isopropyl
The stereochemistry of isoquinoline Reissert compounds: a unique platform for observation of steric and electronic interactions
Abstract Isoquinoline Reissert compounds (2-acyl-1,2-dihydroisoquinaldonitriles) with either 3-H (1) or 3-CH3 (2) substituents and various N-acyl groups have been examined in detail by 1H and 13C NMR
Electronically Rich N-Substituted Tetrahydroisoquinoline 3-Carboxylic Acid Esters: Concise Synthesis and Conformational Studies.
TLDR
Three complementary, glycine donor-based strategies for high yielding synthesis of highly substituted, electronically rich THIQ3CA esters are described and fundamental studies on the synthesis and conformational properties are presented.
Stereochemistry of alkylated isoquinoline Reissert compounds
Abstract A series of alkylated isoquinoline Reissert compounds (2-acyl-1-alkyl-1,2-dihydroisoquinoline-1-nitriles) with either 3-H (3) or 3-CH3 (4) substituents was examined by 1H, 13C, and 19F NMR
Synthesis and radioligand binding studies of bis-(8-isopropyl-isoquinolinium) derivatives as ligands for apamin-sensitive sites on cloned SK2 and SK3 channels.
TLDR
Molecular studies showed that the optimal conformation of compound 2d fits well with the SK pharmacophore model, with the m-xylyl derivative having the best profile in terms of affinity and selectivity for SK3/SK2 channels.

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TLDR
This paper could serve as a general literature citation when one or more of the open-source SH ELX programs (and the Bruker AXS version SHELXTL) are employed in the course of a crystal-structure determination.
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