Bis-penicillamine enkephalins possess highly improved specificity toward delta opioid receptors.

  title={Bis-penicillamine enkephalins possess highly improved specificity toward delta opioid receptors.},
  author={Henry I. Mosberg and Robin Hurst and Victor J. Hruby and Kelvin Wai Cheak Gee and Henry I. Yamamura and James J Galligan and Thomas F. Burks},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={80 19},
The conformationally restricted, cyclic, disulfide-containing, enkephalin analogs [2-D-penicillamine, 5-L-penicillamine]enkephalin [(D-Pen2,L-Pen5]enkephalin) and [2-D-penicillamine, 5-D-penicillamine]enkephalin [(D-Pen2,D-Pen5]enkephalin) were synthesized by solid-phase methods. Selectivities of these analogs for a single class of opioid receptor were investigated by examining relative potencies in the mouse vas deferens assay, in which the functional receptor is the delta receptor, versus the… CONTINUE READING

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