Bis-huperzine B: highly potent and selective acetylcholinesterase inhibitors.

@article{Feng2005BishuperzineBH,
  title={Bis-huperzine B: highly potent and selective acetylcholinesterase inhibitors.},
  author={Song Feng and Zhifei Wang and Xuchang He and Suxin Zheng and Yu Xia and Hualiang Jiang and Xican Tang and Donglu Bai},
  journal={Journal of medicinal chemistry},
  year={2005},
  volume={48 3},
  pages={655-7}
}
By targeting dual active sites of AChE, a series of bis-huperzine B analogues with various lengths of the tether were designed, synthesized, and tested for their inhibition and selectivity. The most potent bis-huperzine B (5g) exhibited 3900-fold increase in AChE inhibition and 930-fold greater in selectivity for AChE vs BuChE than its parent huperzine B. 

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