Bis-basic-substituted polycyclic aromatic compounds. A new class of antiviral agents. 8. Bis-basic derivatives of carbazole, dibenzofuran, and dibenzothiophene.

@article{Albrecht1977BisbasicsubstitutedPA,
  title={Bis-basic-substituted polycyclic aromatic compounds. A new class of antiviral agents. 8. Bis-basic derivatives of carbazole, dibenzofuran, and dibenzothiophene.},
  author={Wilhelm Albrecht and Richard W. Fleming and S W Horgan and Gregory D. Mayer},
  journal={Journal of medicinal chemistry},
  year={1977},
  volume={20 3},
  pages={364-71}
}
A series of bisalkamine esters, bis-basic ethers, and bis-basic ketones of carbazole, N-ethylcarbazole, dibenzofuran, and dibenzothiophene was synthesized and evaluated for antiviral activity. The series also included two bis-basic alkanes of N-ethylcarbazole and one bis-basic carboxamide of dibenzofuran. Structure-activity relationships indicated that… CONTINUE READING