Bis-allylic hydroxylation of polyunsaturated fatty acids by hepatic monooxygenases and its relation to the enzymatic and nonenzymatic formation of conjugated hydroxy fatty acids.

@article{Oliw1993BisallylicHO,
  title={Bis-allylic hydroxylation of polyunsaturated fatty acids by hepatic monooxygenases and its relation to the enzymatic and nonenzymatic formation of conjugated hydroxy fatty acids.},
  author={Ernst H. Oliw and Irene D. Brodowsky and Lena H{\"o}rnsten and Mats H{\'a}mberg},
  journal={Archives of biochemistry and biophysics},
  year={1993},
  volume={300 1},
  pages={434-9}
}
[14C]Linoleic acid was incubated with phenobarbital-induced rat liver microsomes and formation of cis-trans-conjugated hydroxy fatty acids was investigated. 13-Hydroxy-9Z,11E-octadecadienoic acid (13-HODE), 9-hydroxy-10E,12Z-octadecadienoic acid (9-HODE), and three novel metabolites were identified, viz. 11-hydroxy-9Z,12Z-octadecadienoic acid (11-HODE), 8… CONTINUE READING