Bis-N-norgliovictin, a small-molecule compound from marine fungus, inhibits LPS-induced inflammation in macrophages and improves survival in sepsis.

@article{Song2013BisNnorgliovictinAS,
  title={Bis-N-norgliovictin, a small-molecule compound from marine fungus, inhibits LPS-induced inflammation in macrophages and improves survival in sepsis.},
  author={Yuxian Song and Huan Dou and Wei Gong and Xianqin Liu and Zhiguo Yu and Erguang Li and Ren Xiang Tan and Yayi Hou},
  journal={European journal of pharmacology},
  year={2013},
  volume={705 1-3},
  pages={49-60}
}
Sepsis is a highly lethal disorder characterized by systemic inflammation, and Toll-like receptor 4 (TLR4) in macrophages plays a crucial role in modulating innate immune response and outcome of sepsis. During the screening of natural products against inflammation, we identified bis-N-norgliovictin, a small-molecule compound isolated from marine-derived fungus, significantly inhibited lipopolysaccharide (LPS, ligand of TLR4)-induced tumor necrosis factor-α (TNF-α) production in RAW264.7 cells… CONTINUE READING
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