Bis(hydroxyphenyl)methane—bisphenol F—metabolism by the HepG2 human hepatoma cell line and cryopreserved human hepatocytes

@article{Dumont2011BishydroxyphenylmethanebisphenolFB,
  title={Bis(hydroxyphenyl)methane—bisphenol F—metabolism by the HepG2 human hepatoma cell line and cryopreserved human hepatocytes},
  author={Coralie Dumont and Elisabeth Perdu and Georges de Sousa and Laurent Debrauwer and Roger Rahmani and J. -P. Cravedi and Marie Christine Chagnon},
  journal={Drug and Chemical Toxicology},
  year={2011},
  volume={34},
  pages={445 - 453}
}
Bisphenol F (BPF) is present in the environment and as a contaminant of food. Humans may, therefore, be exposed to BPF, and an assessment of this risk is required. BPF has been shown to have genotoxic and endocrine-disruptor properties in a human hepatoma cell line (HepG2), which is a model system for studies of xenobiotic toxicity. In this study, we investigated the ability of HepG2 cells to biotransform BPF, because metabolism may affect the observed effects of BPF, and we compared this… 
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