Bis(2-sulfanylethyl)amino native peptide ligation.

  title={Bis(2-sulfanylethyl)amino native peptide ligation.},
  author={Nathalie Ollivier and Julien Dheur and Reda Mhidia and Annick Blanpain and Oleg Melnyk},
  journal={Organic letters},
  volume={12 22},
The reaction of a peptide featuring a bis(2-sulfanylethyl)amino (SEA) group on its C-terminus with a cysteinyl peptide in water at pH 7 and 37 °C leads to the chemoselective and regioselective formation of a native peptide bond. This method called SEA ligation enriches the native peptide ligation repertoire available to the peptide chemist. Preparation of an innovative solid support which allows the straightforward synthesis of peptide SEA fragments using standard Fmoc/tert-butyl solid phase… CONTINUE READING