Birth outcomes in women who have taken leflunomide during pregnancy.

  title={Birth outcomes in women who have taken leflunomide during pregnancy.},
  author={Christina D. Chambers and Diana L Johnson and Luther Robinson and Stephen R. Braddock and Ronghui Xu and Janina Lopez-Jimenez and Nicole Mirrasoul and Elizabeth Salas and Yunjun J Luo and Shelia Jin and Kenneth Lyons Jones},
  journal={Arthritis and rheumatism},
  volume={62 5},
OBJECTIVE In preclinical reproductive studies, leflunomide was found to be embryotoxic and teratogenic. Women treated with leflunomide are advised to avoid pregnancy; those who become pregnant are advised to reduce fetal exposure through a cholestyramine drug elimination procedure. The present study was undertaken to investigate pregnancy outcomes in women who received leflunomide and were treated with cholestyramine during pregnancy. METHODS Sixty-four pregnant women with rheumatoid… CONTINUE READING
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